Neurogliaform subtypes

Transcriptomic alignment of genetically fate-mapped upper-layers NGCs indicated that they are composed of two subtypes: Dock5- and Lsp1-NGCs. These two subtypes display different molecular architectures, layer distributions and intrinsic properties.

Dock5-NGCs, mainly populating L1, have an enriched NDNF expression, spike earlier than Lsp1-NGCs and display a shallow AHP. Opposedly, Lsp1-NGCs were found dispersed across cortical layers, were late spiking and displayed a deep AHP.

Below you can interrogate the differential gene expression of NGC subtypes.

Select Gene:

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DEGs Volcano postnatal

Expression fold-change (x-axis) vs. subtype model weights (y-axis).

Postnatal landscape (Rxfp1)

Maturation model weights (x-axis) vs. subtype model weights (y-axis).

Postnatal waves (Rxfp1)

Gene expression postnatal waves.
Maturation model weights (x-axis) vs. logRPM RNA (y-axis).